Vacuum Blood Test Tube Cell-Free DNA Room Temperature Stability High Fidelity

Practical Uses & Functions:

• Stabilization: Specifically designed for the long-term, room temperature stabilization of cell-free DNA (cfDNA) in blood, plasma, serum, and other liquid samples, preventing degradation.

• Facilitated Transport: Enables safe sample shipping without freezing, significantly reducing cold chain logistics costs and complexity.

• Streamlined Workflow: Samples can be drawn directly into the tube, eliminating the need for immediate centrifugation or freezing, simplifying pre-analytical processing.

• Release of cfDNA: Stabilizing agents promote cell lysis to release cell-free nucleic acids into circulation and stabilize them immediately.

• Nuclease Inhibition: Contains potent inhibitors that effectively inactivate nucleases (e.g., DNase) in the sample, preventing cfDNA degradation during storage and transport.

• Minimize gDNA Contamination: Optimized formulation minimizes white blood cell lysis, thereby reducing background genomic DNA (gDNA) contamination and improving cfDNA purity.

Key Packaging Advantages:

• Room Temperature Stability: Revolutionizes sample storage by allowing long-term stabilization at ambient temperature (often days to weeks or even months), eliminating reliance on dry ice or ultra-low freezers.

• Draw-and-Stabilize Simplicity: Extremely easy to use - mix blood immediately after draw, bypassing the need for prompt centrifugation.

• High Fidelity Preservation: Superior protection ensures cfDNA integrity, fragment profile, and concentration, providing high-quality template for downstream high-sensitivity assays (e.g., NGS, qPCR, ddPCR).

• Global Compatibility: Cold-chain independence facilitates remote sample collection, centralized shipping, and international transport, enabling multi-center studies and global projects.

• Safety & Reliability: Leak-proof design ensures biosafety; high batch-to-batch consistency guarantees reliable and reproducible results.

• Broad Compatibility: Compatible with various automated liquid handling systems and downstream DNA extraction kits.

Application Scenarios:

• Liquid Biopsy: Cancer early detection, diagnosis, companion diagnostics, treatment response monitoring, recurrence surveillance, and resistance assessment (especially for ctDNA analysis).

• Non-Invasive Prenatal Testing (NIPT): Screening for fetal chromosomal aneuploidies (e.g., Down Syndrome) by analyzing cell-free fetal DNA (cffDNA) from maternal peripheral blood.

• Transplant Rejection Monitoring: Detecting donor-derived cell-free DNA (dd-cfDNA) to assess organ transplant rejection.

• Infectious Disease Detection: Detecting cell-free DNA from pathogens (e.g., viruses, bacteria).

• Genetic Disease Research: Studying circulating fetal or disease-associated DNA.

• Biobanking: Long-term, room-temperature archiving of precious liquid biopsy samples for future research.

• Multi-Center Clinical Trials: Simplifies sample collection, stabilization, and transport across geographically diverse sites, ensuring sample quality consistency.

• Remote Area Sampling: Enables blood sample collection and stabilization in areas lacking cold chain infrastructure.