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- GMP factory High purity peptide raw material carperitide peptide cas 89213-87-6
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Product Specification
Carperitide (CAS 89213-87-6)
Chemical Name: Atrial Natriuretic Peptide (ANP) (1-28), human; α-hANP
Synonyms: Carperitide; ANP (1-28) human; Atrial Natriuretic Factor (1-28); HANF
CAS No.: 89213-87-6
Molecular Formula: C₁₂₇H₂₀₃N₄₅O₃₉S₃
Molecular Weight: 3080.44
Amino Acid Sequence:
H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
(Disulfide bridge: Cys⁷–Cys²³)
Physical & Chemical Properties
- Appearance: White to off-white lyophilized powder
- Purity (HPLC): ≥98.0%
- Single Impurity: ≤1.0%
- Peptide Content: ≥80.0%
- Acetate Content: 5.0–12.0% (acetate salt)
- Water Content: ≤10.0%
- Density: 1.55±0.1 g/cm³ (predicted)
- Storage: -20°C, sealed, protect from light and moisture; lyophilized
- Solubility: Soluble in water (clear, colorless solution)
- Stability: Stable under recommended storage; avoid repeated freeze-thaw cycles
Description
Carperitide is a 28‑amino‑acid peptide hormone identical to human α‑atrial natriuretic peptide (α‑hANP), produced by recombinant or solid‑phase synthesis. It is a key endogenous regulator of cardiovascular homeostasis and fluid‑electrolyte balance, secreted by atrial myocytes in response to stretch/volume overload.
Mechanism of action:
- Binds to NPR‑A receptors on vascular smooth muscle and renal cells → activates guanylyl cyclase → raises cGMP → vasodilation (reduces afterload) and natriuresis/diuresis (reduces preload)
- Inhibits RAAS: suppresses renin, angiotensin II, aldosterone
- Inhibits endothelin‑1 secretion → further vasodilation
- Reduces sympathetic tone → lowers heart rate and blood pressure
Key Applications
- Cardiovascular Research: Heart failure, hypertension, vasodilation, natriuresis, cGMP signaling
- Pharmacology: Tool for studying NPR‑A, RAAS, and endothelin pathways; development for acute heart failure
- Clinical (Research Use Only): Acute decompensated heart failure (reduces preload/afterload, relieves symptoms)
- Biochemical Studies: Fluid balance, renal physiology, cardiac endocrinology
Company Details
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Business Type:
Manufacturer,Distributor/Wholesaler,Exporter
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Total Annual:
5000000-6000000
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Employee Number:
50~100
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Ecer Certification：
Verified Supplier
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