Beijing Bovita Biomed Co.,Ltd.
| CAS | 122111-03-9 |
| Supply Ability | 1000kg/month |
| Expiry | 36 months |
| Stocks | Available |
| Payment Terms | L/C,D/A,D/P,T/T,Western Union |
| Packaging Details | Drum |
| Appearance | white powder |
| Name | Gemcitabine HCL |
| delivery time | 3-5 days |
| Model Number | BVP013 |
| Place of Origin | Suzhou |
| Brand Name | Bovita |
| Certification | ISO/GMP |
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Product Specification
| CAS | 122111-03-9 | Supply Ability | 1000kg/month |
| Expiry | 36 months | Stocks | Available |
| Payment Terms | L/C,D/A,D/P,T/T,Western Union | Packaging Details | Drum |
| Appearance | white powder | Name | Gemcitabine HCL |
| delivery time | 3-5 days | Model Number | BVP013 |
| Place of Origin | Suzhou | Brand Name | Bovita |
| Certification | ISO/GMP | ||
| High Light | GMP factory Gemcitabine HCL Powder ，high purity Gemcitabine HCL API ，Gemcitabine HCL CAS 122111-03-9 | ||
Gemcitabine (Gemcitabine HCl)
CAS No: 122111-03-9
Synonyms: 2'-Deoxy-2',2'-difluorocytidine, dFdC, Gemzar, LY-188011
Molecular Formula: C₉H₁₁F₂N₃O₄·HCl
Molecular Weight: 299.66
Product Overview
Gemcitabine HCL is a pyrimidine nucleoside analog with potent antitumor activity. As a DNA synthesis inhibitor, it disrupts cancer cell proliferation by blocking DNA replication and repair, triggering cell cycle arrest and apoptosis. Widely used in chemotherapy regimens, it targets multiple solid tumors and is a cornerstone in oncology research and treatment.
Key Specifications
Purity: ≥98% (HPLC), typically 99%+
Appearance: White to off-white crystalline powder
Solubility: Soluble in water (19 mg/mL at 25°C); slightly soluble in methanol; practically insoluble in
Storage: Desiccate, protect from light, store at -20°C for long-term stability
Quality Control: Compliant with USP/EP standards; COA, HPLC, NMR, and MS data available
Mechanism of Action
Gemcitabine HCl exerts cytotoxic effects via two active metabolites:
dFdCDP: Inhibits ribonucleotide reductase, depleting deoxyribonucleotide pools required for DNA synthesis.
dFdCTP: Incorporates into DNA strands, blocking chain elongation and inducing DNA damage.
It specifically targets S-phase cells and blocks G1-to-S phase transition, maximizing antitumor efficacy.
Applications
Oncology Treatment: First-line therapy for pancreatic cancer, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and bladder cancer.
Combination Therapy: Synergizes with platinum-based s (cisplatin), taxanes, and targeted therapies to enhance treatment response.
Research Use: Essential reagent for cancer cell biology, resistance studies, and antitumor development.
Packaging & Shipping
Standard Packaging: 10 mg, 50 mg, 100 mg, 1 g, 5 g, 10 g (custom sizes available)
Shipping: Room temperature for short transit; cold chain (-20°C) for bulk orders; worldwide delivery with secure packaging
Quality Assurance
Certifications: GMP, ISO 9001, REACH compliant
Documentation: COA, SDS, HPLC chromatogram, NMR spectrum, and customs clearance documents provided
Shelf Life: 24 months under recommended storage conditions
Why Choose Us?
High Purity: Consistent ≥98% HPLC purity with strict impurity control
Competitive Pricing: Factory-direct supply with flexible MOQs
Reliable Supply: Large inventory for prompt delivery
Technical Support: Professional oncology and chemistry consultation available
Company Details
Business Type:
Manufacturer,Distributor/Wholesaler,Exporter
Year Established:
2016
Total Annual:
5000000-6000000
Employee Number:
50~100
Ecer Certification：
Verified Supplier
About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b... About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...
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