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Osimertinib Mesylate Intermediate CAS 1421373-66-1
Items
Standards
Results
Appearance
White to light yellow solid powder
Light yellow solid powder
Identification
By IR
Complies
By HPLC
Complies
Solubility
Soluble in Dimethylsulfoxide,slightly soluble in Ethanol and Acetonitrile,with pH dependent aqueous solubility
Complies
Water Content(KF)
≤ 1.00%
0.38%
Residue on Ignition
≤ 0.10%
0.07%
Heavy Metals
≤ 20ppm
Complies
Mesylate
15.20%~18.20%
17.20%
Residual Solvents
Acetonitrile: ≤410ppm
ND
Acet: ≤5000ppm
2500ppm
Tetrahydrofuran: ≤720ppm
ND
Related Substances
Maximum single impurity: ≤0.20%
0.05%
Total impurities: ≤1.00%
0.08%
Assay (HPLC basis on drying)
98.00%~102.00%
99.96%
Particle Size
D90: ≤100µm
Complies
Reference Standard
In-house Standard
Conclusion
The product complied to In-house standard.
Storage
Preserve in tight,light-resistant containers in a cool place
Product Overview
Osimertinib Mesylate is a potent EGFR (Epidermal Growth Factor Receptor) inhibitor, specifically classified as a third-generation, covalent, irreversible, and mutation-selective agent designed for advanced cancer treatment applications.
Primary Applications
Cancer Treatment: Primarily used in the treatment of non-small cell lung cancer (NSCLC) that has developed resistance to first- and second-generation EGFR inhibitors, particularly those harboring the T790M mutation.
Therapeutic Agent in Clinical Trials: Currently being investigated in clinical trials for other types of cancers, exploring its potential as a broad-spectrum antitumor agent.
Combination Therapy: Researchers are exploring the use of Osimertinib Mesylate in combination with other therapies to enhance treatment efficacy and overcome resistance.
Key Mechanisms of Action
Inhibition of EGFR Mutations: Binds covalently and irreversibly to the EGFR, particularly the T790M mutation, effectively inhibiting its signaling pathways and tumor growth.
Improved Patient Outcomes: By targeting resistant EGFR mutations, Osimertinib Mesylate has demonstrated improved progression-free survival and overall survival in clinical trials.
>500kg: Sea shipping recommended (FOB, CFR, or CIF service)
For high-value products: Air shipping and express delivery recommended for safety
We accept customer-specified shipping methods and can recommend the optimal shipping solution to ensure safe and timely delivery of your products.
Frequently Asked Questions
Can I get a free sample?
We can provide free samples; customers only need to pay for shipping costs.
How can I trust your company?
Our ownership team has over 16 years of experience in chemical raw materials. We have established long-term relationships with customers and partners through consistent quality and reliable service. Our vision is to obtain wide customer recognition through high-quality procurement and exceptional service.
How do you guarantee product quality?
All products comply with national and international testing standards. Quality certificates are available upon request.
Can you use customer-specific labeling and packaging?
Yes, we accommodate custom labeling and packaging requirements. Please provide your specifications and we will assist accordingly.
What is your delivery time and method?
We typically ship within 3-5 working days after payment confirmation. Shipping options include sea, air, or express delivery with door-to-door service available.
Company Details
Bronze Gleitlager
,
Bronze Sleeve Bushings
and
Graphite Plugged Bushings
from Quality China Factory
Business Type:
Manufacturer,Distributor/Wholesaler,Exporter
Year Established:
2016
Total Annual:
5000000-6000000
Employee Number:
50~100
Ecer Certification：
Verified Supplier
About Us
Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...
About Us
Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...
