Shijiazhuang Zhengzhong Technology Co., Ltd
| Supply Ability | 200 sets / days |
| Design Standards | GB150-2011 |
| Color | Customized |
| Material | steel or stainless steel |
| Products | Tanks, Pressure Vessels, Reactors, Heat Exchangers, Towers |
| Payment Terms | L/C,T/T |
| Applications | Chemical, pharmaceutical, petroleum and petrochemical, new energy industries |
| Delivery Time | 2 months |
| Sizes | Customized |
| Certification | ISO 9001,CE, NSF/ANSI 61, WRAS, ISO 28765, LFGB, BSCI, ISO 45001 |
| Place of Origin | China |
| Brand Name | Center Enamel |
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Product Specification
| Supply Ability | 200 sets / days | Design Standards | GB150-2011 |
| Color | Customized | Material | steel or stainless steel |
| Products | Tanks, Pressure Vessels, Reactors, Heat Exchangers, Towers | Payment Terms | L/C,T/T |
| Applications | Chemical, pharmaceutical, petroleum and petrochemical, new energy industries | Delivery Time | 2 months |
| Sizes | Customized | Certification | ISO 9001,CE, NSF/ANSI 61, WRAS, ISO 28765, LFGB, BSCI, ISO 45001 |
| Place of Origin | China | Brand Name | Center Enamel |
| High Light | Fermenter reactor pressure vessel design ，Fermenter reactor working principles ，Fermenter reactor industrial applications | ||
What Is a Fermenter Reactor? Design, Principles & Applications
Answering the core question: What is a fermenter reactor, and how does it grow microorganisms into valuable biochemicals? A fermenter reactor is a sterile, aerated vessel that cultivates bacteria, yeast, or mammalian cells under controlled temperature (30-37 degree C), pH (5-7.5), and dissolved oxygen (DO above 30 percent saturation). Mechanical agitation at 50-200 rpm with sparged air delivers a volumetric mass-transfer coefficient kLa of 50-400 per hour, sustaining cell densities above 10^9 CFU/mL. Industrial units range from 0.5 m3 pilot tanks to 300 m3 production fermenters, producing antibiotics, enzymes, beer, and bioethanol at yields of 80-95 percent substrate conversion.
Core Operating Principles of Fermenter Reactors
Major Types of Fermenter Reactors
Fermenter Reactor Types Comparison Matrix
Fermenter Type |
Agitation |
Scale Range |
Typical kLa / DO |
Stirred-Tank |
Mechanical Rushton/HE-3 |
0.5-300 m3 |
kLa 100-400/h, DO>30% |
Air-Lift |
Pneumatic (no shaft) |
1-200 m3 |
kLa 50-150/h, low shear |
Hollow-Fiber |
Perfusion, membrane |
0.01-10 m3 |
High cell density, gentle |
Fixed-Bed |
Trickle / packed |
0.1-50 m3 |
Immobilized cells |
Frequently Asked Questions (FAQ)
Q: What is kLa and why is it critical?
A: kLa is the volumetric mass-transfer coefficient describing how fast oxygen enters the liquid; insufficient kLa starves cells, cutting growth rate mu and product titer.
Q: How is a fermenter kept sterile?
A: SIP steam sterilizes the vessel and lines at 121-134 degree C, while 0.2 micrometer hydrophobic or HEPA filters sterilize incoming air and trap exhaust, preventing contamination.
Q: What is fed-batch fermentation?
A: Nutrient is added gradually instead of all at once, avoiding high substrate concentrations that inhibit cells and raising final yield to 80-95 percent.
Q: Which fermenter best suits shear-sensitive cells?
A: Air-lift and hollow-fiber bioreactors provide low-shear, bubble-driven or membrane-based mixing ideal for mammalian and plant cells.
Company Details
Business Type:
Manufacturer
Year Established:
1989
Employee Number:
500~600
Ecer Certification：
Verified Supplier
Shijiazhuang Zhengzhong Technology Co.,Ltd is a professional manufacturer dedicated to the design and fabrication of bolted storage tanks since 2008. Our products range includes Glass-Fused-to-Steel (GFS) tanks, fusion bonded epoxy tanks, stainless steel tanks, galvanized steel tanks a... Shijiazhuang Zhengzhong Technology Co.,Ltd is a professional manufacturer dedicated to the design and fabrication of bolted storage tanks since 2008. Our products range includes Glass-Fused-to-Steel (GFS) tanks, fusion bonded epoxy tanks, stainless steel tanks, galvanized steel tanks a...
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