Shijiazhuang Zhengzhong Technology Co., Ltd
| Supply Ability | 200 sets / days |
| Design Standards | GB150-2011 |
| Material | steel or stainless steel |
| Products | Tanks, Pressure Vessels, Reactors, Heat Exchangers, Towers |
| Color | Customized |
| Payment Terms | L/C,T/T |
| Applications | Chemical, pharmaceutical, petroleum and petrochemical, new energy industries |
| Delivery Time | 2 months |
| Sizes | Customized |
| Certification | ISO 9001,CE, NSF/ANSI 61, WRAS, ISO 28765, LFGB, BSCI, ISO 45001 |
| Place of Origin | China |
| Brand Name | Center Enamel |
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Product Specification
| Supply Ability | 200 sets / days | Design Standards | GB150-2011 |
| Material | steel or stainless steel | Products | Tanks, Pressure Vessels, Reactors, Heat Exchangers, Towers |
| Color | Customized | Payment Terms | L/C,T/T |
| Applications | Chemical, pharmaceutical, petroleum and petrochemical, new energy industries | Delivery Time | 2 months |
| Sizes | Customized | Certification | ISO 9001,CE, NSF/ANSI 61, WRAS, ISO 28765, LFGB, BSCI, ISO 45001 |
| Place of Origin | China | Brand Name | Center Enamel |
| High Light | SIP reactor sterilization design ，pressure vessel sterilization applications ，SIP reactor pressure vessel | ||
What Is a SIP Reactor? Sterilization, Design & Applications
Answering the core question: What is a SIP reactor, and how does in-place steam sterilization guarantee aseptic operation? An SIP reactor is a vessel engineered to be sterilized in situ with saturated steam at 121-134 degree C for 15-30 min, achieving a sterility assurance level (SAL) of 10 to the minus 6 - a probability of a non-sterile unit below one in a million. Thermocouple mapping validates that every surface, including dead-legs, reaches the kill temperature. Sterile 0.2 micrometer vents, double mechanical seals with barrier fluid, and aseptic valves keep the reactor at below 1 CFU/100 mL after cooling, enabling aseptic bioprocessing in 0.05-20 m3 vessels without removal to an autoclave.
Core Operating Principles of SIP Reactors
Major Types of SIP Reactors
SIP Reactor Components Comparison Matrix
SIP Component |
Sterilization Method |
Temp / Time |
Assurance |
Vessel Shell |
Saturated steam |
121-134 degree C / 15-30 min |
SAL 10^-6 |
Vent Filter |
Steam-in-place |
121 degree C / 30 min |
0.2 micrometer sterile |
Transfer Lines |
SIP + aseptic valve |
121 degree C / 20 min |
<1 CFU/100 mL |
Seals (DMS) |
Barrier fluid sterile |
Continuous |
No ingress |
Frequently Asked Questions (FAQ)
Q: What does SAL 10 to the minus 6 mean for an SIP reactor?
A: Sterility Assurance Level of 10 to the minus 6 means the probability of a non-sterile unit is less than one in a million after the validated steam cycle.
Q: Why steam rather than chemical sterilization?
A: Saturated steam at 121-134 degree C penetrates all wetted surfaces and leaves no toxic residue, ideal for aseptic pharma and bioprocess use.
Q: How is the SIP cycle proven effective?
A: Thermocouple mapping shows the coldest point reaches the kill temperature for the full dwell; biological indicators (Geobacillus) may confirm the log reduction.
Q: What keeps the reactor sterile after cooling?
A: 0.2 micrometer sterile vents, double mechanical seals with sterile barrier fluid, and aseptic diaphragm valves prevent microbial ingress during transfer and hold.
Company Details
Business Type:
Manufacturer
Year Established:
1989
Employee Number:
500~600
Ecer Certification：
Verified Supplier
Shijiazhuang Zhengzhong Technology Co.,Ltd is a professional manufacturer dedicated to the design and fabrication of bolted storage tanks since 2008. Our products range includes Glass-Fused-to-Steel (GFS) tanks, fusion bonded epoxy tanks, stainless steel tanks, galvanized steel tanks a... Shijiazhuang Zhengzhong Technology Co.,Ltd is a professional manufacturer dedicated to the design and fabrication of bolted storage tanks since 2008. Our products range includes Glass-Fused-to-Steel (GFS) tanks, fusion bonded epoxy tanks, stainless steel tanks, galvanized steel tanks a...
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