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LDG Series Ribbon Single-Cone Vacuum Dryer, GMP Compliant for Pharmaceutical API Drying
Product Overview
The LDG series ribbon type single cone vacuum mixer dryer is specifically configured for pharmaceutical API, pharmaceutical intermediates and heat-sensitive crystalline powder drying under GMP hygienic conditions. Featuring 316L stainless steel contact parts, CIP online cleaning and SIP online sterilization capabilities.
This vertical, fully enclosed batch vacuum drying equipment integrates drying, mixing and material dispersion functions. The vessel features a single cone structure with an internal hollow heating ribbon agitator. Both the external heating jacket and hollow ribbon can be fed with heat transfer medium simultaneously, achieving dual-path heating.
Operating under high vacuum and low temperature conditions, the ribbon drives material in up-and-down circulation turnover motion, ensuring uniform heating. The fixed vessel design eliminates rotary vacuum joints for better vacuum stability, while bottom hemisphere valve discharge ensures thorough material removal with no residue.
Dual heating structure: Vessel jacket + hollow ribbon supply heat simultaneously, significantly increasing effective heating area and drying efficiency.
Active ribbon agitation: Continuous material turnover disperses lumps; prevents filter cake and viscous materials from sticking to walls.
Fixed vessel without rotation: No rotary vacuum joint, excellent overall sealing, stable operation under high vacuum conditions.
Bottom large-diameter hemisphere valve discharge: Cone hopper structure enables almost complete material discharge with no dead corners.
Fully enclosed batch operation: Suitable for heat-sensitive, easily oxidized and toxic materials; solvent recoverable.
Simple operation: Automated batch control; available as single machine or complete system with vacuum unit and condensation recovery.
Working Principle
Wet material is fed into the cone vessel through the top feed port. The jacket and hollow ribbon are fed with hot water/thermal oil/low pressure steam while the vessel maintains high vacuum to lower solvent vaporization temperature.
The variable frequency driven ribbon agitator rotates, lifting material upward from the cone bottom along the vessel wall. Material falls back to the bottom by gravity, forming continuous circulation turnover that constantly renews the heating surface and accelerates solvent volatilization.
Volatilized solvent vapor passes through the top dust filter and is extracted by the vacuum unit, with optional external condenser for solvent recovery. After drying completion, the bottom hemisphere discharge valve opens for direct discharge.
Core advantages: Jacket + hollow ribbon dual heating, active agitation material turnover, low temperature vacuum drying, closed batch operation, residue-free discharge.
Technical Parameters
Model
Total Volume (L)
Effective Volume (L)
Agitator Speed (r/min)
LDG-100
100
70
5-35
LDG-200
200
140
5-35
LDG-300
300
210
5-35
LDG-500
500
350
5-35
LDG-1000
1000
650
5-35
LDG-1500
1500
850
5-35
LDG-2000
2000
1400
5-35
LDG-2500
2500
1750
5-35
LDG-3000
3000
2100
5-35
LDG-3500
3500
2450
5-35
LDG-4000
4000
2800
5-35
LDG-5000
5000
3500
5-35
LDG-7500
7500
4800
5-35
General parameters: Working vacuum: -0.06 ~ -0.098 MPa | Working temperature: room temp ~ 120°C (adjustable by heat transfer medium) | Filling coefficient: 0.3-0.7 | Contact material: 304/316L stainless steel customizable | Operation mode: batch production.
Application Fields
Pharmaceutical API industry: Pharmaceutical intermediates, crystalline API and filter cake vacuum drying, meeting GMP clean production.
Food and biological industry: Food additives, plant extracts and crystalline powder low-temperature drying.
Fine chemical industry: Catalysts, dye intermediates, various filter cakes and easily oxidized powder drying, with solvent recovery.
New energy and new materials: Lithium battery precursor, inorganic powder and crystalline material drying.
Pesticide industry: Pesticide intermediates and filter cake crystalline material closed drying.
Frequently Asked Questions
Q1: What is the core difference between the LDG single cone ribbon dryer and a double cone rotary vacuum dryer?
A: The LDG vessel is fixed and relies on internal hollow ribbon for active agitation and material turnover, with jacket + ribbon dual heating and higher drying efficiency. It can process filter cake and easily agglomerated viscous materials. The double cone dryer relies on vessel rotation without internal agitation, giving weak processing capability for agglomerated filter cake. The LDG has no rotary vacuum joint, more stable vacuum system, supports CIP/SIP, and is more suitable for pharmaceutical high-cleanliness conditions.
Q2: Can it process filter cake and viscous agglomerated materials?
A: Yes. The internal ribbon continuously circulates the material, dispersing lumps and renewing the heating surface, making it the advantageous model for filter cake drying. It is not suitable for large-particle hard abrasive materials, as hard particles will wear the ribbon and the vessel inner wall mirror surface.
Q3: Is it continuous production equipment?
A: The LDG is batch equipment: feeding - drying - discharging is one complete batch. For continuous drying processes, other types of equipment are required.
Q4: Can solvent be recovered?
A: Yes, the equipment can be equipped with a condenser and recovery tank to form a solvent recovery system, condensing and collecting the volatilized solvent.
Q5: Does it support CIP cleaning and SIP sterilization?
A: Yes, the hygienic configuration can be added with a CIP spray ball and SIP steam sterilization interface, meeting pharmaceutical GMP production requirements.
Q6: What are the filling requirements?
A: The recommended filling coefficient is 0.3-0.7. Material should neither be too little nor full-tank filling, ensuring the ribbon can fully drive material circulation for uniform drying.
Contact us for detailed specifications and a factory quote.
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