A50: Poloxamer L64 L65 Polyethylene Polypropylene Glycol Cas 9003-11-6 Propylene

Product Specification

L64 / L65 

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Polyethylene-polypropylene glycol / Synperonic pe(R) / Poloxamer
Chemical composition: Propylene Glycol Block Polyether

L64  Polyethylene Polypropylene Glycol

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Make low foam detergent or defoamer. L64 are used to prepare synthetic detergent with low foam and high detergency;
L64 can be used as pesticide emulsifiers, coolants and lubricants in metal cutting and grinding. It is used as a lubricant when rubber is vulcanized.
L64 can effectively prevent the formation of hard scale in oil pipeline and be used for the recovery of secondary oil.

L65 Polyethylene Polypropylene Glycol

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L65 is mainly used in wool spinning industry. As wool protective agent, adding about 0.3% in wool carbonization process can reduce wool scale damage, enhance single fiber strength by 10% and reduce spinning end breakage rate by 10%

Packaging and Storage

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Package: 1000Kg/ IBC drum or 200Kg / drum (Net weight).

Storage and Transportation: Store and transport as general chemicals. Keep in a dry and ventilated place. Shelf life is two years.

Shelf Life: two years.

Performance and Application

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1. As an emulsifier and stabilizer: Poloxamer is one of the few synthetic emulsifiers used in intravenous emulsions as a water in oil emulsifier. Dosage: 0.1% to 5%. The emulsion prepared with this product has fewer milk particles, usually within 1 μ Below m, the absorption rate is high. Stable physical properties, able to withstand hot pressure sterilization and low-temperature freezing. Application example: Fat emulsion infusion for injection. The prescription for Lipomul is 150g cottonseed oil, 12g soy phospholipids, 3g Pluronic F68, 40g glucose, and 100ml injection water.

2. As a solvent enhancer: This product can increase the surface solubility of various drugs, such as salicylic acid, indomethacin, and metronidazole, by forming micelles with surfactants. Taking salicylic acid as an example, salicylic acid can be solubilized in two Pluronic types, Pluronic L65 and Pluronic F68. Each mole of Pluronic L65 can solubilize 1.3mol of salicylic acid, and each mole of Pluronic F68 can solubilize 0.93mol of salicylic acid, indicating the stable solubility of salicylic acid in different concentrations of Pluronic. The solubility of salicylic acid in Pluronic per minute (mg/ml x 10000). The solubility of salicylic acid in F68 gradually increases with increasing concentration of the active agent, but in L65, the solubility rapidly increases to its maximum with increasing concentration, but gradually decreases thereafter.

3. As an absorption enhancer: On the one hand, this product slows down intestinal peristalsis, prolongs the retention time of the drug in the gastrointestinal tract, and increases absorption, thereby improving the bioavailability of oral formulations. On the other hand, this product has good skin compatibility, increases skin permeability, and can promote the absorption of topical agents.

4. As slow release materials: solid products with large molecular weight are used as adhesives, coating materials, etc. to prepare tablets, capsules, gel, etc. to achieve the purpose of slow release and controlled release, and have achieved satisfactory results. Dosage: 5% to 15%.

Technical Information

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