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Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

China Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

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Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

MOQ： 1set
Price： USD30,000-300,000
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Payment Terms	T/T
Supply Ability	1-10sets/month
Delivery Time	30-90 days
Packaging Details	exporting package
Capacity	required by customers
Optional device	Micro feeder device
Supplier	Chinese factory
Control system	PLC
Parts	famous brand
feeding type	horizontal feeding type
Features	no waters and solvents
Warranty	one year
Material	SS304, 316L
Core Selling Point	Famous Brand Plc
Applicable Industry	pharma, chemical, food industry
Brand Name	Shengman
Model Number	LG
Certification	CE
Place of Origin	changzhou

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Product Details
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Product Specification


Payment Terms	T/T	Supply Ability	1-10sets/month
Delivery Time	30-90 days	Packaging Details	exporting package
Capacity	required by customers	Optional device	Micro feeder device
Supplier	Chinese factory	Control system	PLC
Parts	famous brand	feeding type	horizontal feeding type
Features	no waters and solvents	Warranty	one year
Material	SS304, 316L	Core Selling Point	Famous Brand Plc
Applicable Industry	pharma, chemical, food industry	Brand Name	Shengman
Model Number	LG	Certification	CE
Place of Origin	changzhou

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

The application of Roller Compactor (dry granulation machine) in the production of western medicine (chemical drugs, biopharmaceuticals, etc.) is very mature and extensive, and it is one of its most classic and core application fields. With the deepening of continuous manufacturing and QbD concept, the importance of roller compactor in the field of Western medicine intelligent manufacturing will be further enhanced due to its easy control of parameters and integration.

Many active ingredients (APIs) in Western medicine have the following characteristics:

Sensitive to moisture and heat: Many APIs are unstable when exposed to water or heat, and are prone to hydrolysis, oxidation, or crystal transformation.

Low dose: The API content in the prescription is very low (such as less than 1%), and it needs to be evenly mixed with a large amount of excipients. Wet granulation may cause uneven content.

Insolubility: About 70% of modern new drugs are insoluble, and wet granulation may exacerbate their dissolution problems, while dry granulation does not affect their inherent dissolution characteristics.

Compliance requirements: Strictly avoid solvent residue and comply with international regulatory guidelines such as ICH.

The Roll Compactor can perfectly solve these inherent problems of Western medicine API, so roller compactor is the preferred process and equipment for Western medicine granulation production.

Model	LG100	LG100E	LG160	LG200	LG240	LG360
Capacity (kg/h)	1.5-15	12-40	50-150	100-240	160-320	360-720
Rated power (kw)	3.47	3.53	7.24	11.37	15.94	32.55
Roller size (D*W)	100*25	100*40	160*50	200*75	240*100	360*150

For large production scale application, we provide double-supporting roller model

Model	LGS200	LGS240	LGS360	LGS500
Capacity (kg/h)	200-400	300-640	1200-2000	1500-3000
Rated power (kw)
Roller size (D*W)

Main application scenarios and functions of dry granulation machine

1. As a pretreatment for direct tablet pressing (most commonly used)

Scenario: When the mixture of API and excipients has poor fluidity, insufficient compressibility, or there is a risk of separation, it cannot be directly pressed into tablets.

Function: Dry Granulator is used to make granules with excellent fluidity and compressibility, while ensuring that the mixing uniformity is not disrupted. This is an effective supplement to the direct compression process.

2. Handling highly active or harmful substances

Scenario: Production of highly effective drugs such as cytotoxic drugs and hormones.

Function: The entire dry granulation process is carried out in a fully enclosed system, greatly reducing the risk of operators being exposed to hazardous dust and ensuring production safety.

3. Production of water sensitive materials

Scenario: Production of easily hydrolyzed materials (such as aspirin, certain antibiotics, proton pump inhibitors, etc.).

Function: Completely avoid the use of water or organic solvents, fundamentally eliminate the risk of hydrolysis, and ensure the chemical stability of the product.

4. Improve materials dissolution behavior (under specific circumstances)

Scenario: For certain materials, the high-pressure rolling process may result in partial microcrystallization or crystal defects, which can actually increase the specific surface area and improve the dissolution rate.

Attention: This requires further research as pressure may also cause crystal transformation or have the opposite effect.

5. Production of special dosage forms such as effervescent tablets and chewable tablets

Scenario: The acid and base sources (such as citric acid and sodium bicarbonate) in effervescent tablets must not come into contact with water.

Function: Roller compactor is the only or best choice for producing intermediate particles in this type of dosage form, ensuring that all ingredients are absolutely dry before compression.

Why Choose Us:
We are a leading Chinese manufacturer specializing in dry granulation equipment. With extensive experience in custom engineering solutions, we ensure that each machine meets your unique production requirements, improving efficiency and product quality.

Call-to-Action:
Contact us today to discuss your production needs and get a customized dry granulation solution!

Company Details

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Business Type:

Manufacturer 
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Year Established:

2011 
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Total Annual:

10000000-20000000
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Employee Number:

50~100 
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Jiangsu Shengman Drying Equipment Engineering Co.,Ltd, established in 2011, known as a local leading high-tech enterprise, is located in Zhenglu town, Changzhou, Jiangsu, China. Shengman is a large-scale production enterprise in China drying industry with a registered capital of 100,000,000 RMB, spe... Jiangsu Shengman Drying Equipment Engineering Co.,Ltd, established in 2011, known as a local leading high-tech enterprise, is located in Zhenglu town, Changzhou, Jiangsu, China. Shengman is a large-scale production enterprise in China drying industry with a registered capital of 100,000,000 RMB, spe...

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zhenglu town, tianning district, changzhou city, JIangsu Province
https://www.spraydryingmachine.com/

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