Pharmaceutical Fermentation Mycelium Recovery Decanter Centrifuge LW355 GMP

Antibiotic and fine chemical fermentation broths contain mycelium, cells and undissolved medium solids that must be removed quickly and gently before downstream extraction and purification. HUADING LW355 pharmaceutical fermentation mycelium recovery decanter centrifuge separator performs this critical clarification duty for GMP regulated facilities, recovering more than 99 percent of the suspended biomass while minimizing product loss in the cake. The compact 355 mm bowl machine is sized perfectly for clinical scale and small production fermenters between 5 and 50 cubic meters, delivering consistent separation batch after batch with complete documentation for validation.

The fully enclosed design keeps the broth under inert gas blanketing when required and prevents aerosol release, protecting both the product and the operators. Wetted parts in SS316L with a mirror finish and crevice free welds satisfy clean in place requirements, while the scroll discharge conveys the mycelium cake continuously to a closed receiver. Because the LW355 operates as a closed system between the fermenter harvest line and the extraction vessels, it eliminates the open handling steps and filter aid consumption associated with plate and frame filtration, reducing both contamination risk and operating cost.

• GMP compliant design: SS316L wetted parts, Ra 0.8 micron surface finish, sanitary tri clamp connections and full drainability support clean room installation and CIP validation.
• Closed product path: Inert gas blanketing and contained discharge protect oxygen sensitive broths and prevent fugitive dust or aerosol escape during harvesting.
• High biomass capture: A centrifugal force of 3500 g retains fine mycelial filaments and cell debris, producing a clear supernatant suitable for direct solvent extraction or chromatography.
• Gentle solids handling: Optimized feed acceleration and conveyor geometry minimize shear, reducing cell breakage and the release of intracellular impurities into the broth.
• Complete documentation: Material certificates, weld maps, surface finish reports and factory test records accompany every machine to support user validation dossiers.
• Compact clean footprint: The small footprint machine fits into existing clean utility areas and can be supplied on a mobile frame with casters for flexible use between production suites.
• Repeatable automatic cycles: PLC controlled feeding, washing and discharging cycles with data logging support batch traceability required by pharmaceutical quality systems.

The LW355 recovers mycelium from antibiotic fermentation broth including penicillin, cephalosporin and tetracycline processes, as well as amino acid, enzyme, vitamin and organic acid fermentations. It also dewaters spent fermentation biomass from single cell protein and probiotic production. The clarified broth advances to solvent extraction, evaporation or chromatographic purification with lower solids loading, improving resin life and extractor throughput. Facilities producing biopesticides and microbial inoculants use the same machine to concentrate whole cell cultures. For every application HUADING prepares an application report based on representative broth samples, so the process performance is proven before the equipment is ordered.

Pharmaceutical grade machines receive individual inspection with documented surface roughness measurement, material traceability and hydrostatic testing of the bowl assembly. The LW355 ships in a dedicated plywood case with desiccant and humidity indicators, and all sanitary connections are sealed with protective caps. The documentation file includes the material certificate, welding certificate, dimensional drawing, GA drawing, P and ID suggestion, electrical scheme, IQ OQ support documentation and operation manual. HUADING offers FAT at the factory with customer witness testing, supervised installation and commissioning support, and a twelve month warranty with priority spare parts service for the pharmaceutical industry.