Product Specification

Integrated Washing, Sterilizing, Filling & Sealing Line (5-25ml)

High-Capacity Aseptic Automation for Bioactive Liquids and Oral Formulations

Product Overview

In the high-stakes production of advanced Life sciences formulations and concentrated oral liquids, maintaining absolute environmental control across multiple packaging stages is critical. The Lingyao Integrated Liquid Filling Line is a fully cohesive automation ecosystem designed for 5ml to 25ml standard glass vials and oral liquid bottles.

By seamlessly combining the LYQCL ultrasonic washing machine, the LYASMR hot air circulation sterilization oven, and the LYYGZ filling and capping unit, this system delivers an exceptional production capacity of 6,000 to 22,000 Bottles Per Hour (BPH). It provides a compact, continuous workflow that ensures strict cGMP compliance for high-value Healthcare solutions.

The Cause: Contamination Risks in Fragmented Production

Relying on standalone machines for washing, depyrogenation, and filling introduces severe production bottlenecks. Manual transfer between these stages dramatically increases the risk of microbial and particulate contamination, jeopardizing the safety of premium Bioactive liquids.

Furthermore, legacy filling mechanisms often suffer from unacceptable volumetric drift (often up to ±2%), causing catastrophic financial losses when dosing expensive active ingredients. Finally, disjointed equipment often lacks synchronized control, leading to frequent bottle jams, high glass breakage rates, and exhaustive maintenance downtime.

The Solution: Seamless Integration and Ultrasonic Precision

The Lingyao automated platform eliminates these vulnerabilities through perfectly synchronized mechanical and electrical integration. To guarantee flawless cleanliness, the vertical ultrasonic washing module utilizes independent water and sterile air spray nozzles, completely eradicating cross-contamination. Vials then pass directly into the tunnel-type hot air circulation oven, where high-speed laminar flow ensures uniform heat distribution for complete pyrogen removal.

Once inside the aseptic filling core, advanced servo-driven pumps dispense the Life sciences formulations with an ultra-precise accuracy of ≤ ±0.5%. The entire operation is governed by a Premium European PLC architecture, ensuring seamless bottle transfers that reduce the overall line breakage rate to an industry-leading < 0.5%.

Specifications

Application Scenarios

• Advanced Life Sciences: Complete closed-loop aseptic packaging for sensitive recombinant proteins and high-value Bioactive liquids.

• Premium Wellness Supplements: Turnkey sterile processing for concentrated liquid vitamins, antioxidant serums, and regenerative wellness formulas.

• Specialized Oral Liquids: High-speed, highly accurate dosing for viscous syrups and essential nutritional suspensions.

How It Works

The automated process initiates at the vertical rotary washing station, where ultrasonic cavitation and independent spray needles rigorously clean the vials without dead angles. The bottles automatically transfer into the laminar-flow hot air circulation oven for preheating, high-speed sterilization, and controlled cooling.

Upon entering the strictly monitored filling core, the tracking nozzles precisely dispense the liquid formulations without splashing. Immediately following the fill, the synchronized capping station applies the closures. The Premium European PLC architecture continuously monitors the line, providing real-time fault diagnostics and ensuring that only perfectly sealed Healthcare solutions are discharged.

How To Choose the Right Configuration

To maximize your facility's operational efficiency, evaluate the following configuration criteria:

• Assess Throughput Requirements: Depending on your upstream processing volumes, the line can be calibrated to operate steadily at your exact required output, scaling up to a maximum of 22,000 BPH.

• Evaluate Layout Constraints: This system features a highly compact, space-saving design (under 10 meters in length), making it the ideal choice for facilities looking to upgrade to full automation without requiring massive cleanroom expansions.

• Plan for Regional Compliance: Supported by our TachoCraft Thailand manufacturing base and global logistics, we provide specialized tropicalized machine builds and full IQ/OQ/PQ validation dossiers. This ensures rapid customs clearance and regulatory platform registrations (such as SASO/SABER) in the Middle East and African markets.

Frequently Asked Questions (FAQ)

Q1: How does the ultrasonic washing machine prevent cross-contamination? A: The washing module utilizes highly independent spray needles. Each needle is strictly dedicated to a single cleaning medium (such as purified water, WFI, or sterile compressed air). This specific design absolutely prevents cross-contamination and ensures thorough cleaning.

Q2: Can the line handle both vials and standard oral liquid bottles? A: Yes. The system is designed with versatile, quick-change format parts. A trained operator can swap the star wheels and guide rails to seamlessly transition between vials requiring rubber stoppers/crimps and oral liquid bottles requiring screw or ROPP caps.

Q3: What lifecycle support is provided for international deployments? A: We deliver extensive Accompanying Production Services worldwide. This includes 24/7 remote diagnostics, complete Site Installation, Commissioning, SAT (Site Acceptance Testing), and hands-on operator training to ensure your commercial production advances smoothly.