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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
Product Introduction
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
Core Specification Table(8 items)
Index
Data
CAS Number
877397-65-4
Molecular Formula
C₈H₇Cl₂FO
Molecular Weight
209.045
Appearance
Off-white crystalline powder
Melting Range
42–46 ℃
Boiling Point
261.3 ℃ (760 mmHg)
Available Purity
98%, 99%
Density
1.4 g/cm³
Core Product Properties
1. Pure S Chiral Configuration
This compound only contains S enantiomer without racemic mixtures. Optical rotation test data keeps consistent across different batches, and chiral structure will not convert to R configuration under sealed dark storage.
2. Uniform Crystal Morphology
Fine crystalline particles without caking or foreign impurities, dissolves evenly in common organic solvents to reduce experimental reaction errors.
3. Selective Solubility Trait
Slightly soluble in methanol, ethanol and DMSO; insoluble in water, alkane and solvents, matching solvent system for pharmaceutical chiral synthesis.
4. Reliable Thermal Stability
No racemization or molecular cracking below 100 ℃. Thermal decomposition only occurs when temperature exceeds 260 ℃, releasing halogen-containing by-products.
5. Active Hydroxyl Functionality
The chiral hydroxyl group supports esterification, substitution and cross-coupling reactions, acting as key unit to construct crizotinib molecular skeleton.
6. Strict Impurity Control
Moisture, single unknown impurity and halogen residue are limited within inspection thresholds for intermediates, fit for lab test and pilot scale-up preparation.
7. Anti-Oxidation Storage Stability
Chlorine and fluorine substitution strengthens molecular stability. Shelf life reaches 2 years under airtight cool environment with no obvious quality decline.
8. Stable Batch Consistency
Fixed element proportion and molecular composition for every batch, delivering steady conversion rate in downstream synthesis steps.
Application Scope
Essential synthetic precursor of crizotinib for non-small cell lung cancer targeted therapy
Raw material for asymmetric catalysis and chiral compound structural modification lab tests
Intermediate for developing new small-molecule kinase inhibitor
Storage & Handling Guidance
Short-term storage: 2–8 ℃, fully sealed and shaded environment
Long-term storage: -20 ℃ airtight container to extend service cycle
Isolate from strong oxidants, high-temperature heat sources and ultraviolet radiation
Reduce frequent opening of packaging to avoid moisture absorption and light-induced racemization
Physical Properties
Solid chiral aromatic alcohol under ambient temperature. Slightly soluble in methanol, insoluble in water. Crystalline structure maintains stable optical rotation under sealed storage.
Chemical Properties
No spontaneous decomposition at room temperature. Hydroxyl group supports esterification reaction. Single S configuration avoids racemic impurities during downstream synthesis. Thermal decomposition releases hydrogen halide under high heat.
Application Scope
Chiral building block for compound preparation, laboratory asymmetric synthesis research, fine chemical intermediate production.
Storage Guidance
Seal container tightly, place inside low temperature dry space, isolate from strong oxidants and direct sunlight exposure.
Company Details
Bronze Gleitlager
,
Bronze Sleeve Bushings
and
Graphite Plugged Bushings
from Quality China Factory
Business Type:
Manufacturer
Total Annual:
20000000-30000000
Employee Number:
>10
Ecer Certification：
Verified Supplier
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. is a technology-driven CDMO enterprise integrating R&D, custom synthesis and production. Adhering to the tenets of customer-centricity and quality supremacy, we deliver premium services and high-quality products to all clients.
Our techn...
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. is a technology-driven CDMO enterprise integrating R&D, custom synthesis and production. Adhering to the tenets of customer-centricity and quality supremacy, we deliver premium services and high-quality products to all clients.
Our techn...
