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GMP factory supply high purity Apraglutide peptide CAS 1295353-98-8 Apraglutide

China GMP factory supply high purity Apraglutide peptide CAS 1295353-98-8 Apraglutide

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GMP factory supply high purity Apraglutide peptide CAS 1295353-98-8 Apraglutide

MOQ： 1g
Price： 220USD
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Payment Terms	L/C,D/A,D/P,T/T,Western Union
Test Method	HPLC HNMR
Einecs	1295353-98-8
Specification	1g/5g/bag
Delivery Time	3-7 days
Casnumber	Varies by peptide
Packagingmaterial	PVC bottle or aluminium foil bag
Supply Ability	5kg/month
Color	white
Type	Glp-2
Packaging Details	PVC bottle or aluminium foil bag
Stocks	Yes
Appearence	Powder
Puritylevel	Pharmaceutical grade
Product Type	Custom Peptide
Storage Temp	2-8°C
Lead Time	3-5 working days after payment
Model Number	BVR14
Place of Origin	Wuhan
Certification	DMF
Brand Name	Bovita

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Product Details
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Product Specification


Payment Terms	L/C,D/A,D/P,T/T,Western Union	Test Method	HPLC HNMR
Einecs	1295353-98-8	Specification	1g/5g/bag
Delivery Time	3-7 days	Casnumber	Varies by peptide
Packagingmaterial	PVC bottle or aluminium foil bag	Supply Ability	5kg/month
Color	white	Type	Glp-2
Packaging Details	PVC bottle or aluminium foil bag	Stocks	Yes
Appearence	Powder	Puritylevel	Pharmaceutical grade
Product Type	Custom Peptide	Storage Temp	2-8°C
Lead Time	3-5 working days after payment	Model Number	BVR14
Place of Origin	Wuhan	Certification	DMF
Brand Name	Bovita
High Light	GMP Apraglutide peptide powder ，high purity Apraglutide CAS 1295353-98-8 ，research-grade Apraglutide peptide

Apraglutide (CAS 1295353-98-8) Product Details

Apraglutide, with CAS Number 1295353-98-8, is a synthetic, long-acting glucagon-like peptide-2 (GLP-2) agonist, also known as FE 203799. It is a 33-amino acid modified peptide with four amino acid substitutions compared to the native GLP-2, which enhances its stability and resistance to degradation by dipeptidyl peptidase-4 (DPP-4). As a high-purity peptide hormone, it strictly complies with international pharmaceutical standards (GMP, USP, EP) and is widely used in global medical research, clinical trials and pharmaceutical R&D, especially in the fields of intestinal disorder treatment and gastrointestinal function regulation.

Product Basic Information

Item	Details
CAS Number	1295353-98-8
Product Name	Apraglutide; FE 203799; GLP-2 Analogue
Chemical Formula	C₁₇₂H₂₆₃N₄₃O₅₂
Molecular Weight	Approx. 3765.24
Appearance	White to Off-White Solid Powder
Purity	≥98% (HPLC); ≥99% available for research grade
Solubility	DMSO: ~100 mg/mL (26.56 mM, ultrasonic assistance recommended); Insoluble in Water; Homogeneous suspension in CMC-Na (≥5 mg/mL)
Storage Condition	Sealed, Protected from Light; Powder: -20°C for 3 years, 4°C for 2 years; Dissolved: -80°C for 6 months, -20°C for 1 month; Avoid repeated freeze-thaw cycles and moisture exposure
Shelf Life	36 Months under Proper Storage Conditions (powder)
Peptide Sequence	His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Nle-D-Phe-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH₂ (HGDGSFSDE-Nle-d-F-TILDLLAARDFINWLIQTKITD-NH₂)

Pharmacological Action & Clinical Applications

Mechanism of Action

Apraglutide acts as a full agonist of the GLP-2 receptor, selectively activating GLP-2 receptors in the gastrointestinal (GI) tract by mimicking the effects of native GLP-2. Its key effects include stimulating intestinal growth, enhancing intestinal fluid and nutrient absorption, promoting intestinal epithelial healing, and improving intestinal barrier integrity and function. Its long-acting property is attributed to its high binding affinity to plasma proteins and resistance to DPP-4 degradation, with a longer half-life compared to other GLP-2 agonists, allowing for less frequent dosing (e.g., once-weekly subcutaneous injection). The incorporation of aminocaproic acid (Ahx) in place of methionine at position 10 further reduces degradation by lysine-targeting proteolytic enzymes, extending its circulating half-life.

Main Clinical Uses

Intestinal Disorder Research: Primarily studied for the treatment of short bowel syndrome (SBS), especially short bowel syndrome with intestinal failure (SBS-IF), helping reduce patients’ dependence on parenteral (intravenous) nutrition by improving intestinal absorption capacity.
Graft-Versus-Host Disease (GVHD) Research: Investigated for the prevention and treatment of gastrointestinal GVHD, a complication of bone marrow or stem cell transplantation, by enhancing intestinal barrier function and reducing intestinal inflammation.
Pharmaceutical R&D: Serves as a key tool for researching the GLP-2 receptor pathway and developing new s for intestinal disorders, with ongoing clinical trials evaluating its safety, efficacy, and pharmacokinetics in different patient populations.
Animal Model Research: Widely used in animal experiments (e.g., neonatal piglet models of SBS with total ileal resection) to study intestinal adaptation and linear intestinal growth, providing a basis for clinical application research.

Contraindications & Adverse Reactions

Contraindications: Prohibited for patients with hypersensitivity to any component of the product, severe gastrointestinal obstruction, and those with severe hepatic or renal impairment.

Adverse Reactions: Common reactions may include mild gastrointestinal discomfort (nausea, abdominal distension), transient fatigue, and injection site reactions. Long-term use may lead to intestinal hyperplasia and electrolyte disturbances. Regular monitoring of intestinal function, hepatic and renal function, and electrolytes is recommended during use.

Export Compliance & Trade Information

Regulatory Attribute

Apraglutide is classified as a peptide hormone in China, subject to the administration of Import and Export License (Regulatory Code: L). It complies with GMP, USP, EP and other international pharmaceutical standards, and meets the regulatory requirements of major global markets such as the EU and the United States, including FDA orphan designations for SBS and GVHD treatment, and EU orphan designation for SBS treatment.

HS Code & Declaration Elements

Recommended HS Code: 2934999001 (Peptide hormones and their derivatives; subject to the latest customs code of the importing country); For finished dosage forms, refer to HS Code 3004 (Medicaments for therapeutic or prophylactic uses). Note that ECCN (Export Control Classification Number) is distinct from HS Code and should be confirmed based on local regulations for US exports.

Declaration Elements: CAS Number, Product Name, Purity, Usage (Medical/Research), Composition, Brand, Peptide Sequence, Amino Acid Substitution Information, etc.

Export Documentation Requirements

Export Sales Certificate (valid for 3 years), issued by the provincial regulatory authority of China.
Import License or official certification of the importing country (if required), especially complying with FDA regulations for the US market, CEP requirements for the EU market, and EAR requirements for US exports, as well as orphan related certifications.
Relevant qualifications: GMP Certificate, Production Approval Number, Sales Contract, etc.
Test Reports: COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), peptide sequence verification report, purity test report (HPLC/MS), and endotoxin test report (available upon request).

Logistics & Packaging

Packaging: Aluminum foil bag or glass vial, labeled with ", Protect from Light, Keep Dry", peptide sequence and amino acid substitution information; sealed packaging to prevent moisture, contamination and peptide degradation. Vacuum-packed options are available upon request.

Transportation: Ambient temperature shipping is acceptable for short-distance transportation (stable at room temperature for several days during shipping and customs clearance); cold chain transportation (shipping with blue ice) is recommended for long-distance or high-temperature environments to ensure product quality. Avoid extreme temperature changes and repeated freeze-thaw cycles.

Quality Assurance & After-Sales Service

Strict Quality Control: Each batch of products undergoes HPLC, MS and peptide sequence verification tests to ensure purity, stability and structural accuracy; endotoxin testing (≤50EU/mg) is available upon request. Single impurity ≤2% and peptide content ≥75.0% are guaranteed for research and medical grade products.
Customized Service: We can provide customized packaging and specifications according to customer needs, including small-volume research-grade products (≥99% purity) and large-volume medical-grade products, as well as customized solvent formulation guidance for in vivo and in vitro use.

Company Details

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Business Type:

Manufacturer,Distributor/Wholesaler,Exporter 
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Year Established:

2016 
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Total Annual:

5000000-6000000
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Employee Number:

50~100 
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Ecer Certification：

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About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b... About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...

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