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GMP factory sale High Purity Difelikefalin peptide powder cas 1024828-77-0 Difelikefalin peptide with DMF
Difelikefalin peptide powder, CAS 1024828-77-0, high-purity CR845, research-grade KOR agonist, difelikefalin for pruritus research, peripheral opioid peptide, lyophilized difelikefalin
Difelikefalin (CAS 1024828-77-0), also known as CR845, FE-202845, and Korsuva™, is a synthetic, peripherally selective κ-opioid receptor (KOR) agonist. It acts by binding to peripheral KORs to modulate pruritus, inflammatory signals, and without significant central nervous system penetration, avoiding central adverse effects like respiratory depression. This tetrapeptide is a key research tool for studying itch mechanisms, neuro-immune interactions, and analgesic development.
Parameter
Specification
Chemical Name
Difelikefalin (Free Base)
CAS Number
1024828-77-0
Molecular Formula
C₃₆H₅₃N₇O₆
Molecular Weight
~679.85 g/mol
Purity
≥98.0% (HPLC), with single impurity ≤1.0%
Appearance
White to off-white lyophilized powder
Solubility
Water ≥100 mg/mL; DMSO ≥90 mg/mL
Storage
-20°C, sealed, dry, protected from light
Shelf Life
2 years at -20°C; 1 year at -20°C (open); 6 months/-1 month in solvent at -80°C/-20°C
Key Features & Advantages
Peripheral Selectivity: Limited blood-brain barrier penetration minimizes central side effects.
High Potency & Selectivity: Targets KORs with minimal cross-reactivity to other opioid receptors.
Rigorous QC: HPLC, LC-MS, and NMR confirmation for batch consistency.
Low Endotoxin: ≤1000 EU/mg (standard for research-grade peptides).
Flexible Packaging: Available in mg to g scales with custom vial options.
Research Applications
Pruritus Research: Investigating uremic pruritus in hemodialysis patients and chronic itch mechanisms.
& Inflammation: Studying peripheral analgesia and anti-inflammatory pathways in post-op and chronic models.
Neuro-Immunology: Exploring KOR-mediated immune cell modulation and neuroinflammation.
Pharmaceutical R&D: Reference standard for formulation, bioactivity, and safety profiling.
Neuroscience: Analyzing peripheral opioid signaling and sensory neuron function.
Quality Control & Documentation
Each batch includes:
HPLC purity & identity verification
LC-MS molecular confirmation
¹H-NMR structural consistency
Endotoxin, heavy metal, and microbial limits testing
Full COA, SDS, and batch traceability (available on request)
Handling & Storage
For Research Use Only. Not for human/veterinary clinical use.
Store lyophilized powder at -20°C upon receipt; aliquot to avoid freeze-thaw cycles.
Ship ambient for short durations; maintain cold chain for long-term transport.
Global express delivery with temperature-controlled packaging.
In-stock orders ship within 24–48 hours; discreet, secure packaging for customs compliance.
Compliance
Manufactured in ISO 9001/13485-certified facilities to meet global research standards.
Company Details
Bronze Gleitlager
,
Bronze Sleeve Bushings
and
Graphite Plugged Bushings
from Quality China Factory
Business Type:
Manufacturer,Distributor/Wholesaler,Exporter
Year Established:
2016
Total Annual:
5000000-6000000
Employee Number:
50~100
Ecer Certification:
Verified Supplier
About Us
Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...
About Us
Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...