Beijing Bovita Biomed Co.,Ltd.
| Cas no. | 2012558-47-1 |
| Assay | 99% |
| Appearance | White Powde |
| Sample | Availiable |
| Grade | Phamaceutical Grade |
| Payment Terms | L/C,D/A,D/P,T/T,Western Union |
| Supply Ability | 5kg/month |
| Purity | 99%min |
| Shelf life | 2 Years |
| Type | Amino Acids |
| GMP factory | Yes |
| Packaging Details | 10g/aluminium foil bag |
| Brand Name | Bovita |
| Certification | ISO/GMP |
| Place of Origin | SICHUAN |
View Detail Information
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Product Specification
| Cas no. | 2012558-47-1 | Assay | 99% |
| Appearance | White Powde | Sample | Availiable |
| Grade | Phamaceutical Grade | Payment Terms | L/C,D/A,D/P,T/T,Western Union |
| Supply Ability | 5kg/month | Purity | 99%min |
| Shelf life | 2 Years | Type | Amino Acids |
| GMP factory | Yes | Packaging Details | 10g/aluminium foil bag |
| Brand Name | Bovita | Certification | ISO/GMP |
| Place of Origin | SICHUAN | ||
| High Light | GMP bulevirtide peptide powder ，bulevirtide peptide powder 99% purity ，bulevirtide peptide powder CAS 2012558-47-1 | ||
Bulevirtide Peptide Powder (CAS 2012558-47-1)
Bulevirtide (also known as Myrcludex B or Hepcludex) is a first-in-class linear lipopeptide consisting of 47 amino acids with an N-terminal myristoylation group. This lyophilized powder is a synthetic derivative of the hepatitis B virus (HBV) pre-S1 domain, designed to target the sodium-taurocholate co-transporting polypeptide (NTCP) receptor, the key entry receptor for both HBV and hepatitis delta virus (HDV) in hepatocytes.
Key Specifications
CAS Number 2012558-47-1
Molecular Formula C₂₄₈H₃₅₅N₆₅O₇₂
Molecular Weight 5398.91 Da
Purity ≥98%–99.8% (HPLC)
Appearance White to off-white lyophilized powder
Solubility Soluble in 50% acetic acid (1 mg/mL); sparingly soluble in water
Storage -20°C (desiccated); -80°C for long-term storage
Sequence Myr-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH₂
Bulevirtide acts as a high-affinity NTCP inhibitor (IC₅₀ ≈ 80–140 pM):
Viral Entry Blockade: Binds specifically to NTCP on hepatocytes, competitively inhibiting HBV and HDV attachment and entry.
Antiviral Potency: Suppresses HBV/HDV infection at sub-nanomolar concentrations, preventing viral replication and spread.
NTCP Modulation: Inactivates NTCP function without significantly impairing bile salt transport at therapeutic doses.
Applications
Antiviral Research: Essential for studying HBV/HDV entry mechanisms, viral-host interactions, and NTCP biology.
Development: Preclinical and clinical development for chronic hepatitis D (HDV) infection, often in combination with HBV nucleoside analogs.
Liver Disease Research: Investigations into compensated cirrhosis, viral hepatitis co-infections, and hepatocyte receptor function.
Biomedical Assays: Positive control for NTCP inhibition assays and HBV/HDV entry inhibition studies.
Quality Assurance
Manufactured under GMP-compliant facilities with rigorous quality control.
Validated by HPLC, Mass Spectrometry (MS), and Amino Acid Analysis for identity, purity, and sequence accuracy.
Supplied with Certificate of Analysis (COA) and Safety Data Sheet (SDS).
Why Choose Our Bulevirtide?
Ultra-High Purity: ≥98% HPLC grade ensures consistent, reproducible antiviral activity.
Verified Bioactivity: Potent NTCP inhibition confirmed in cell-based assays.
Custom Packaging: Available in 1mg, 5mg, 10mg, and bulk quantities to suit research and production needs.
Global Shipping: Fast, cold-chain delivery to research institutions and pharmaceutical companies worldwide.
Order Information
Product Name: Bulevirtide Peptide Powder
CAS: 2012558-47-1
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Company Details
Business Type:
Manufacturer,Distributor/Wholesaler,Exporter
Year Established:
2016
Total Annual:
5000000-6000000
Employee Number:
50~100
Ecer Certification：
Verified Supplier
About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b... About Us Founded in Fangshan District, Beijing, Bovita is a forward-thinking biotech startup specializing in high-purity peptide products and premium dietary supplement raw materials. Rooted in the rigorous standards of China’s pharmaceutical and chemical industry, we are dedicated to b...
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