Product Specification

Integrated Aseptic Glass Ampoule Washing, Filling, and Sealing Line (1-20ml)

Zero-Carbonization Dosing and Nitrogen Blanketing for Premium Collagen and Peptide Serums

Product Overview

In the rapidly expanding regenerative medicine and high-end cosmeceutical sectors, packaging temperature-sensitive, high-viscosity biologicals—such as hydrolyzed collagen, multi-peptide complexes, and dermal boosters—requires absolute environmental and mechanical control. The Lingyao LYQCL + LYASMR + LYAGF Integrated Ampoule Processing Line is a massive, 10-meter continuous automation architecture engineered to process 1ml to 20ml standard glass ampoules.

Achieving extreme high-speed outputs of up to 40,000 Ampoules Per Hour (for 1-2ml formats), this unified platform flawlessly executes ultrasonic washing, 300°C dry-heat depyrogenation, micro-dosing, and open-flame sealing. Enclosed entirely within a Class 100 (ISO 5) Laminar Airflow environment, it protects the bioactivity of premium anti-aging formulations while delivering an uncompromising dosing precision of ≤ ±0.5%.

The Cause: Collagen Carbonization, Oxidation, and Viscosity Variations

Filling dense, protein-rich serums into narrow glass ampoules introduces severe operational friction that standard liquid fillers cannot overcome:

1. The "Black Spot" Carbonization Crisis: Hydrolyzed collagen and hyaluronic acid are highly viscous and prone to "wire-drawing" (stringing). If a standard nozzle leaves a micro-drop of serum on the inner neck of the ampoule, the subsequent 1000°C open-flame sealing station will instantly burn the protein. This creates a highly visible black carbonized spot, ruining the aesthetic and triggering immediate batch rejection.

2. Oxidative Degradation: Premium bio-active collagen degrades and loses its structural viscosity rapidly when exposed to ambient oxygen. If standard atmospheric air is trapped inside the ampoule during sealing, the anti-aging efficacy of the product is severely compromised.

3. Thermal Shock and Breakage: Transferring delicate glass ampoules between disparate washers, ovens, and fillers causes micro-fractures, leading to catastrophic glass breakage at high production velocities.

The Solution: Anti-Drip Diving Nozzles and Synchronized Flame Sealing

The Lingyao engineering team resolved these high-value biological packaging vulnerabilities through specialized fluid dynamics and unbroken mechanical linkage.

To completely eliminate protein carbonization, the filling station is equipped with Servo-Driven Diving Nozzles with Mechanical Vacuum Suck-Back. The nozzles descend to the very bottom of the ampoule during the fill and rise in perfect synchronization with the liquid level. At the precise millisecond the fill completes, the vacuum instantly snaps the liquid column, ensuring zero dripping or wire-drawing on the ampoule neck, guaranteeing pristine, crystal-clear flame seals.

To protect formulation bioactivity, the system features a Pre- and Post-Fill Nitrogen Blanketing Module. High-purity nitrogen purges the ampoule immediately prior to filling and right before the highly controlled gas/oxygen flame draws and seals the glass tip. The entire 10-meter line—from ultrasonic washing to final sealing—is mechanically synchronized by a centralized PLC, achieving a remarkably low breakage rate of ≤ 1.0% across the entire operation.

Technical Specifications

Targeted Cosmeceutical and Pharmaceutical Applications

• Premium Cosmeceutical Serums: Pristine, carbonization-free filling for high-viscosity anti-aging formulas, including recombinant humanized collagen and multi-peptide dermal boosters.

• Liquid Biologics & Extracts: Low-shear, nitrogen-protected pathways engineered to preserve the molecular integrity of delicate regenerative medicine liquids.

• Essential Nutritional Injectables: High-speed, continuous processing for Vitamin C derivatives and complex skin-brightening solutions requiring strict ISO Class 5 aseptic environments.

Turnkey Global Deployment and Validation Execution

Deploying a 10-meter, 40,000 BPH open-flame aseptic line demands a manufacturing partner with absolute engineering rigor. Built utilizing our advanced TachoCraft Thailand manufacturing base, Lingyao provides a seamless Turnkey Solution tailored for the cosmeceutical and pharmaceutical sectors.

We accompany your capital investment with a comprehensive suite of compliance documentation, fully supporting FDA 21 CFR Part 11 requirements through our advanced HMI/PLC architecture. Our global engineering team delivers exhaustive DQ/IQ/OQ/PQ validation dossiers, FAT/SAT execution, and complete on-site commissioning. This rigorous technical oversight drastically expedites strict regulatory audits and SABER/SASO customs clearances across the Middle East, ensuring your high-value collagen production reaches the market efficiently and securely.